Current Research on Hydroxyapatite Toothpaste Efficacy and Safety

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schematic enamel microcrystals hydroxyapatite
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Last Updated January 2022

This is a current list of every study we’ve found on the safety and efficacy of hydroxyapatite toothpaste. We created this to be a resource for the functional dentist community, so feel free to bookmark it, share it widely with your patients, and email us if you have a study to add.

I must give credit to Jacqueline Carcaramo, RDH who inspired this idea. When we both realized we were keeping our own repository of studies on this topic, we realized we could join forces and publish this database for the benefit of functional dentists and hygienists everywhere.


Studies on Hydroxyapatite Toothpaste Efficacy & Safety

Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis

Based on this systematic review and meta-analysis, it can be concluded that biomimetic hydroxyapatite-containing, fluoride-free oral care products are effective in reducing dental decay, especially in children.

Conclusion: There is good evidence that hydroxyapatite in oral care products in the absence of fluoride effectively reduces caries.


Nano-hydroxyapatite and its applications in preventive, restorative and regenerative dentistry: a review of literature

This study aims to critically summarize the literature about nano-hydroxyapatite, specifically the benefits of using nano-hydroxyapatite for its preventive, restorative, and regenerative applications in dentistry.


Remineralization potential of fully demineralized dentin infiltrated with silica and hydroxyapatite nanoparticles

Demineralized dentin infiltrated with silica NPs appears to encourage heterogeneous mineralization of the dentin collagen matrix following exposure to an artificial saliva solution.


Reconsidering remineralization strategies to include nanoparticle hydroxyapatite.

This in-vitro study documented the deposition of nanoparticle hydroxyapatite on demineralized enamel surfaces after treatment with an experimental remineralization gel. This finding supports consideration of an additional approach to remineralization that includes pH neutralization strategies and nanoparticle hydroxyapatite crystals.


Effect of nano-hydroxyapatite concentration on remineralization of initial enamel lesion in vitro

The purpose of the research was to determine the effect of nano-hydroxyapatite concentrations on initial enamel lesions under dynamic pH-cycling conditions.


Remineralization Potential of Nano-Hydroxyapatite on Initial Enamel Lesions: An in vitro Study

The remineralization effect of nano-HA on demineralized bovine enamel is investigated under pH cycling conditions through surface and cross-sectional microhardness (CSMH) tests and polarized light microscopy (PLM). The percentage of surface microhardness recovery and integrated mineral loss obtained from CSMH tests demonstrated that nano-HA provides better remineralization than micro-HA.


Combined Effects of Nano-Hydroxyapatite and NaF on Remineralization of Early Caries Lesion

The aim of this study was to evaluate the combined effects of a nano-HA and fluoride mouthrinse on an early caries lesion in human enamel using an in vitro cycle remineralization and treatment model.


Effectiveness of nano-hydroxyapatite toothpaste in reducing dentin hypersensitivity: a double-blind randomized controlled trial

A double-blind randomized clinical trial that compared the efficacy in reducing dentin hypersensitivity of a dentifrice formulation containing nano-hydroxyapatite with a fluoride dentifrice and a placebo.


Comparison of Nano-Hydroxyapatite and Sodium Fluoride Mouthrinse for Remineralization of Incipient Carious Lesions

Nano-HA and NAF mouthrinses can greatly enhance remineralization and increase tooth microhardness.


Remineralization Potential of New Toothpaste Containing Nano-Hydroxyapatite

The results showed that there were no significant differences in Vickers Hardness Number values between the two toothpastes (P>0.05). A toothpaste containing nano-sized hydroxyapatite has the potential to remineralize an incipient caries lesion. In addition, the addition of fluoride had no synergistic effect on remineralization.


Enamel remineralization and repair results of Biomimetic Hydroxyapatite toothpaste on deciduous teeth: an effective option to fluoride toothpaste

The study was performed in vitro and in vivo, comparing the hydroxyapatite toothpaste with two others toothpaste containing different fluorine concentrations. The coating effect of the micro-structured Hydroxyapatite nanoparticles reintegrates the enamel with a biomimetic film reproducing the structure and the morphology of the biologic Hydroxyapatite of the enamel. As demonstrated, the coating is due to the deposit of a new layer of apatite, which presents fewer particles than the natural enamel, not based on the chemical—physical changes occurring in fluorinated toothpastes. Moreover, it shows resistance to brushing as a consequence of chemical bonds between the synthetic and natural crystals of the enamel.


Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study

Hydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F) in remineralizing initial caries lesion.

Enamel and dentine remineralization by nano-hydroxyapatite toothpastes

Toothpastes containing n-HAp revealed higher remineralizing effects compared to amine fluoride toothpastes with bovine dentine, and comparable trends were obtained for enamel.


Remineralization of early caries by a nano-hydroxyapatite dentifrice

The purpose of this randomized, double-blind, crossover, in situ study was to evaluate the efficacy of nano-hydroxyapatite (nHAP) dentifrices on caries remineralization and demineralization inhibition. nHAP dentifrice caused remineralization comparable to a fluoride dentifrice, and inhibited caries development, thus suggesting that an nHAP dentifrice can be an effective alternative to fluoride toothpaste.


Synthetic Biomimetic Carbonate-Hydroxyapatite Nanocrystals for Enamel Remineralization

The experimental results point out the possibility to use materials alternative to fluoride compounds which is commonly utilized to contrast the mechanical abrasions and acid attacks. The apatitic synthetic coating is less crystalline than enamel natural apatite, but consists of a new biomimetic apatitic mineral deposition which progressively fills the surface scratches. Therefore the application of biomimetic CHA may be considered an innovative approach to contrast the acid and bacteria attacks.


Fabrication and characterization of remineralizing dental composites containing hydroxyapatite nanoparticles

  • HApNPs allowed Ca2+ and PO43− release in low pHs.
  • HApNPs enable remineralization of caries-like enamel lesions.

Effect of hydroxyapatite nanoparticles on enamel remineralization and estimation of fissure sealant bond strength to remineralized tooth surfaces: an in vitro study

This study investigated the ability of hydroxyapatite nanoparticles (nano-HA) to remineralize enamel, and their effect on sealant microleakage and shear bond strength (SBS).


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